EPPP Psychopharmacology Practice Exam 2025 - Free Psychopharmacology Exam Questions and Study Guide

Haldol is classified as a first-generation antipsychotic, also known as a typical antipsychotic. These medications primarily work by blocking dopamine receptors in the brain, specifically the D2 receptor, which helps to reduce the symptoms of psychosis such as hallucinations and delusions. First-generation antipsychotics are generally more effective for positive symptoms of schizophrenia but are associated with a higher risk of extrapyramidal side effects, including tardive dyskinesia and akathisia.

In contrast, Geodon (Ziprasidone) and Abilify (Aripiprazole) are both second-generation antipsychotics, also called atypical antipsychotics. These medications have a broader mechanism of action, which includes effects on serotonin receptors, potentially leading to a different side effect profile and sometimes a reduced risk of extrapyramidal symptoms. Clozaril (Clozapine) is another atypical antipsychotic, notable for its use in treatment-resistant schizophrenia but is not classified as a first-generation drug.

Understanding the distinctions between these classes of medications is crucial for recognizing their indications, side effects, and mechanisms of action in the treatment of psychotic disorders.